Community
Advocacy
Research &

Education

​"Novel compound has promise for treatment of Huntington's disease" - Mass. General-led study identifies molecular compound with two neuroprotective activities. Please join us in congratulating  HD-CARE Scientific Advisory Board members, Dr. Malcolm Casale  and Dr. Leslie Thompson and Dr. Ryan Lim on the publication of the Mass General News Release.

One on 1 Profile:Geneticist Dr. Nancy Wexler Leads the Fight Against a Dreaded Disease She's at Risk of Developing.

Read More Here

HD Disease Progression

by: Huntington Study Group

UCI team finds method to reduce accumulation of damaging Huntington’s disease protein

Read More...



HD ​Pathology Unfolds

Courtesy: Larry Marsh and judit pallos

IN A FLY'S EYE: The regular repeating structure of the Drosophila melanogaster compound eye is disrupted when polyglutamine (polyQ 108) is expressed, making the fly eye an excellent model for huntingtin-derived pathology. Dissecting the mechanism of neuronal demise in Huntington disease (HD) has had its share of twists and turns. It took a decade to go from marker1 to gene,2 and now, after another decade, the details are beginning to come together.​ Read More Here

UCI HD RESEARCH

Huntington Disease Pathology Unfolds

Dissecting the mechanism of neuronal demise in Huntington disease (HD) has had its share of twists and turns. It took a decade to go from marker1 to gene,2 and now, after another decade, the details are beginning to come together. Three papers published in 2001 focus on two key roles for the pathological form of huntingtin protein--interfering with transcription3,4 and plugging up proteasomes, the cellular trash compactors for misfolded proteins.5 While different, these hypotheses are not mutually exclusive, and may point to multiple effects that inevitably cause the devastating symptoms of HD. Read More Here

Dr. Malcolm Casale;  Dr. Leslie Thompson;  and Dr. Ryan Lim